Article
Induction of senescence in human malignant glioma cells by p16INK4A.
Oncogene - 31 Jul 1997
Uhrbom L, Nistér M, Westermark B
Abstract excerpt
p16INK4A is a G1-specific cell cycle inhibitor which maps to human chromosome 9p21, a region frequently mutated or deleted in cancer cell lines and primary tumors. In glioblastomas the frequency of homozygous deletions is 40-70% making it one of the most common mutations in this tumor type. We have analysed the significance of the loss of this gene in gliomas by introducing the cDNA for p16INK4A into the human...
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