Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The failure in the stabilization of glioblastoma-derived cell lines: spontaneous in vitro senescence as the main culprit.

PloS one - 1 Jan 2014

Stoczynska-Fidelus Ewelina, Piaskowski Sylwester, Bienkowski Michal, Banaszczyk Mateusz, Hulas-Bigoszewska Krystyna, Winiecka-Klimek Marta, Radomiak-Zaluska Anna, Och Waldemar, Borowiec Maciej, Zieba Jolanta, Treda Cezary, Rieske Piotr

Abstract excerpt

Cell line analysis is an important element of cancer research. Despite the progress in glioblastoma cell culturing, the cells isolated from the majority of specimens cannot be propagated infinitely in vitro. The aim of this study was to identify the processes responsible for the stabilization failure. Therefore, we analyzed 56 primary GB cultures, 7 of which were stabilized. Our results indicate that senescence...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Cell Movement

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cellular Senescence

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Glioblastoma

Share to Mitosis

Share to Neoplastic Stem Cells

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 24498027
DOI: 10.1371/journal.pone.0087136
PMCID: PMC3910690

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The failure in the stabilization of glioblastoma-derived cell lines: spontaneous in vitro senescence as the main culprit.PMID 24498027Read ↗

Residual Disease in Glioma Recurrence: A Dangerous Liaison with SenescenceSemantic proximity Read ↗

Spontaneous in vitro senescence of glioma cells confirmed by an antibody against IDH1R132H.Semantic proximity Read ↗

Tumor Cell Escape from Therapy-Induced Senescence as a Model of Disease Recurrence after DormancySemantic proximity Read ↗

P21 Overexpression Promotes Cell Death and Induces Senescence in Human GlioblastomaSemantic proximity Read ↗

P21 Overexpression Promotes Cell Death and Induces Senescence in Human GlioblastomaSemantic proximity Read ↗

Could senescence phenotypes strike the balance to promote tumor dormancy?Semantic proximity Read ↗

Activation of p53 by nutlin-3a induces apoptosis and cellular senescence in human glioblastoma multiforme.Semantic proximity Read ↗

Chemotherapy-induced senescence, an adaptive mechanism driving resistance and tumor heterogeneitySemantic proximity Read ↗

Senescence in neural cell lines: comparative insights from SH-SY5Y and ReNcell VMSemantic proximity Read ↗

Mechanisms of Cell Cycle Arrest and Apoptosis in GlioblastomaSemantic proximity Read ↗

Tumor cell-induced macrophage senescence plays a pivotal role in tumor initiation followed by stable growth in immunocompetent condition.Semantic proximity Read ↗

Tumour cell-induced senescence-like state of macrophages plays a pivotal role in tumour stable growth after tumour cell emergence in immunocompetent conditionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.