Article
Apolipoprotein E in progressive supranuclear palsy in Japan.
Molecular psychiatry - 1 Jul 1997
Sawa A, Amano N, Yamada N, Kajio H, Yagishita S, Takahashi T, Oda M, Arai N, Ikeda K, Tadokoro M, Matsushita M
Abstract excerpt
Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease which shows several psychiatric and neurologic symptoms: pseudobulbar palsy, supranuclear ocular palsy, extrapyramidal rigidity, gait ataxia, and dementia. Almost all cases seem to be sporadic; therefore, the elucidation of risk factors is important to clarify the pathological mechanism. Apolipoprotein E4 (ApoE4) is now well established as a...
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