Article
Induction of multiple PCR-SSCPE mobility shifts in p53 exons in cultures of normal human urothelium exposed to low-dose gamma-radiation.
International journal of radiation biology - 1 Jul 1997
Colucci S, Mothersill C, Harney J, Gamble S C, Seymour C, Arrand J E
Abstract excerpt
We have previously shown that primary explant cultures of human urothelium exposed to low doses of gamma-radiation subsequently accumulate a high level of stable p53 but it was not clear from those studies whether this protein stabilization occurred through an event in another gene involved in p5...
Topics
- Culture Techniques
- Dose-Response Relationship, Radiation
- Exons
- Gamma Rays
- Genes, p53
- Humans
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Single-Stranded Conformational
- Proto-Oncogene Proteins c-bcl-2
- Proto-Oncogene Proteins c-myc
- Tumor Suppressor Protein p53
- Urothelium
