Article
Characterization of HIV-1 protease mutants: random, directed, selected.
Current opinion in biotechnology - 1 Aug 1994
Swanstrom R
Abstract excerpt
The HIV-1 protease is becoming one of the most important proteins in medicine. It is perhaps the most attractive target for development of an anti-HIV-1 therapeutic drug. Given its pre-eminent position in biomedical research, many aspects of the protease are currently coming under close scrutiny. Protease is available from recombinant sources, and numerous structures of the enzyme (with and without bound...
Topics
- DNA Mutational Analysis
- Drug Resistance, Microbial
- HIV Protease
- HIV Protease Inhibitors
- HIV-1
- Mutation