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Article

Conversion of thymidylate synthase into an HIV protease substrate.

The Journal of biological chemistry - 2 Aug 1996

Kupiec J J, Hazebrouck S, Leste-Lasserre T, Sonigo P

Abstract excerpt

Thymidylate synthase (TS) is an essential enzyme of DNA metabolism. We have carried out an extensive insertional mutagenesis of the Escherichia coli TS gene (thyA) using three different methods. Insertion of exogenous sequences at unique restriction sites or at random positions produced defective mutants, whereas comparison of TS sequences from different species allowed us to identify six zones permissive for...

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Source

Identifiers

PMID: 8702491
DOI: 10.1074/jbc.271.31.18465

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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