Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human immunodeficiency virus reverse transcriptase substitutes for DNA polymerase I in Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 1995

Kim B, Loeb L A

Abstract excerpt

We present evidence that human immunodeficiency virus (HIV) reverse transcriptase (RT) can substitute for DNA polymerase I in bacteria. Expression of HIV RT enables an Escherichia coli mutant, polA12 recA718, containing a temperature-sensitive mutation in DNA polymerase I, to grow at a nonpermissive temperature. The plasmid pBR322 contains a DNA polymerase I-dependent origin of replication. Expression of HIV RT...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Replication
Share to Escherichia coli
Share to Genetic Complementation Test

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Plasmids

Share to RNA-Directed DNA Polymerase

Share to Temperature

Source

Open in PubMed Open full text

Identifiers

PMID: 7531338
DOI: 10.1073/pnas.92.3.684
PMCID: PMC42684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human immunodeficiency virus reverse transcriptase substitutes for DNA polymerase I in Escherichia coli.PMID 7531338Read ↗

An Orthogonal T7 Replisome for Continuous Hypermutation and Accelerated Evolution in <i>E. coli</i>Semantic proximity Read ↗

Inhibiting translation elongation can aid genome duplication in Escherichia coli.Semantic proximity Read ↗

Human Immunodeficiency Virus Reverse TranscriptaseSemantic proximity Read ↗

Genetic selection in Escherichia coli for active human immunodeficiency virus reverse transcriptase mutants.Semantic proximity Read ↗

Alternative divalent cations (Zn²⁺, Co²⁺, and Mn²⁺) are not mutagenic at conditions optimal for HIV-1 reverse transcriptase activity.Semantic proximity Read ↗

Conversion of thymidylate synthase into an HIV protease substrate.Semantic proximity Read ↗

Exploring the DNA mimicry of the Ocr protein of phage T7.Semantic proximity Read ↗

An integrated system to study multiply substituted human immunodeficiency virus type 1 reverse transcriptase.Semantic proximity Read ↗

A simple Escherichia coli system for monitoring HIV protease activity: analysis of two temperature-sensitive protease mutants.Semantic proximity Read ↗

An Escherichia coli expression assay and screen for human immunodeficiency virus protease variants with decreased susceptibility to indinavir.Semantic proximity Read ↗

Expression of Moloney murine leukemia virus RNase H rescues the growth defect of an Escherichia coli mutant.Semantic proximity Read ↗

DnaA Protein of Escherichia coli: oligomerization at the E. coli chromosomal origin is required for initiation and involves specific N-terminal amino acids.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.