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Article

Identification and characterization of an operon in Salmonella typhimurium involved in thiamine biosynthesis.

Journal of bacteriology - 1 Aug 1997

Petersen L A, Downs D M

Abstract excerpt

Thiamine pyrophosphate (TPP) is synthesized de novo in Salmonella typhimurium and is a required cofactor for many enzymes in the cell. Five kinase activities have been implicated in TPP synthesis, which involves joining a 4-methyl-5-(beta-hydroxyethyl)thiazole (THZ) moiety and a 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP) moiety. We report here identification of a 2-gene operon involved in thiamine...

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Identifiers

PMID: 9244280
DOI: 10.1128/jb.179.15.4894-4900.1997
PMCID: PMC179339

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