Genetic analysis of metabolic crosstalk and its impact on thiamine synthesis in Salmonella typhimurium.

doi:10.1093/genetics/143.1.37

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Article

Genetic analysis of metabolic crosstalk and its impact on thiamine synthesis in Salmonella typhimurium.

Genetics - 1 May 1996

Petersen L, Enos-Berlage J, Downs D M

Abstract excerpt

The first five steps in de novo purine biosynthesis are involved in the formation of the 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP) moiety of thiamine. We show here that the first enzyme in de novo purine biosynthesis, PurF, is required for thiamine synthesis during aerobic growth on some...

Topics

Carboxy-Lyases
Crosses, Genetic
Genes, Bacterial
Genes, Regulator
Genotype
Glucosephosphate Dehydrogenase
Models, Biological
Pentose Phosphate Pathway
Phenotype
Phosphogluconate Dehydrogenase
Pyrimidines
Salmonella typhimurium
Thiamine
Transduction, Genetic

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