Article
Genetic analysis of metabolic crosstalk and its impact on thiamine synthesis in Salmonella typhimurium.
Genetics - 1 May 1996
Petersen L, Enos-Berlage J, Downs D M
Abstract excerpt
The first five steps in de novo purine biosynthesis are involved in the formation of the 4-amino-5-hydroxymethyl-2-methyl pyrimidine (HMP) moiety of thiamine. We show here that the first enzyme in de novo purine biosynthesis, PurF, is required for thiamine synthesis during aerobic growth on some but not other carbon sources. We show that PurF-independent thiamine synthesis depends on the recently described...
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