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Article

Analysis of ThiC variants in the context of the metabolic network of Salmonella enterica.

Journal of bacteriology - 1 Nov 2012

Palmer Lauren D, Dougherty Michael J, Downs Diana M

Abstract excerpt

In bacteria, the 4-amino-hydroxymethyl-2-methylpyrimidine (HMP) moiety of thiamine is synthesized from 5-aminoimidazole ribotide (AIR), a branch point metabolite of purine and thiamine biosynthesis. ThiC is a member of the radical S-adenosylmethionine (AdoMet) superfamily and catalyzes the complex chemical rearrangement of AIR to HMP-P. As reconstituted in vitro, the ThiC reaction requires AdoMet, AIR, and...

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Identifiers

PMID: 22961850
DOI: 10.1128/JB.01361-12
PMCID: PMC3486400

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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