Analysis of ThiC variants in the context of the metabolic network of Salmonella enterica.

doi:10.1128/JB.01361-12

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Article

Analysis of ThiC variants in the context of the metabolic network of Salmonella enterica.

Journal of bacteriology - 1 Nov 2012

Palmer Lauren D, Dougherty Michael J, Downs Diana M

Abstract excerpt

In bacteria, the 4-amino-hydroxymethyl-2-methylpyrimidine (HMP) moiety of thiamine is synthesized from 5-aminoimidazole ribotide (AIR), a branch point metabolite of purine and thiamine biosynthesis. ThiC is a member of the radical S-adenosylmethionine (AdoMet) superfamily and catalyzes the complex chemical rearrangement of AIR to HMP-P. As reconstituted in vitro, the ThiC reaction requires AdoMet, AIR, and...

Topics

Amino Acid Sequence
Bacterial Proteins
Gene Expression Regulation, Bacterial
Genetic Variation
Methionine
Molecular Sequence Data
Molecular Structure
Mutation
Pantothenic Acid
Salmonella typhimurium
Thiamine

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Identifiers

PMID: 22961850
DOI: 10.1128/JB.01361-12
PMCID: PMC3486400

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