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Article

Isolation and characterization of new thiamine-deregulated mutants of Bacillus subtilis.

Journal of bacteriology - 1 Dec 2005

Schyns Ghislain, Potot Sébastien, Geng Yi, Barbosa Teresa M, Henriques Adriano, Perkins John B

Abstract excerpt

In bacteria, thiamine pyrophosphate (TPP) is an essential cofactor that is synthesized de novo. Thiamine, however, is not an intermediate in the biosynthetic pathway but is salvaged from the environment and phosphorylated to TPP. We have isolated and characterized new mutants of Bacillus subtilis that deregulate thiamine biosynthesis and affect the export of thiamine products from the cell. Deletion of the ydiA...

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Identifiers

PMID: 16291685
DOI: 10.1128/JB.187.23.8127-8136.2005
PMCID: PMC1291275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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