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Article

Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts.

Current biology : CB - 12 Mar 1998

McConnell B B, Starborg M, Brookes S, Peters G

Abstract excerpt

After a limited number of population doublings (PDs), cultures of normal mammalian diploid cells undergo an irreversible growth arrest known as replicative senescence [1]. As well as contributing to cellular ageing, senescence is viewed as an important mechanism of tumour suppression by preventing the emergence of immortal cell clones [2-4]. Senescent cells have a number of characteristics that distinguish them...

Topics

Animals
Cell Cycle Proteins
Cells, Cultured
Cellular Senescence
Cyclin-Dependent Kinase Inhibitor p15
Cyclin-Dependent Kinase Inhibitor p16
Cyclin-Dependent Kinase Inhibitor p21
Cyclin-Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinases
Cyclins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Enzyme Inhibitors

Fibroblasts

Fluorescent Antibody Technique

Humans

Microtubule-Associated Proteins

Phenotype

RNA

Time Factors

Source

Identifiers

PMID: 9512419
DOI: 10.1016/s0960-9822(98)70137-x

Provenance

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