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Article

Origins of G<sub>1</sub> arrest in senescent human fibroblasts

1 Jun 1995

Abstract excerpt

Human diploid fibroblasts have a finite proliferative lifespan in culture, at the end of which they are arrested with G1 phase DNA contents. Upon serum stimulation, senescent cells are deficient in carrying out a subset of early signal transduction events such as activation of protein kinase C and induction of c-fos. Later in G1, they uniformly fail to express late G1 genes whose products are required for DNA...

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PMID: 7575495
DOI: 10.1002/bies.950170610

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