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Article

Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1.

Cancer research - 1 Jun 1995

Bond J A, Blaydes J P, Rowson J, Haughton M F, Smith J R, Wynford-Thomas D, Wyllie F S

Abstract excerpt

Although the cyclin-dependent kinase inhibitor p21SDI1 (WAF1/CIP1) has been proposed as the mediator of p53-induced cell cycle arrest following DNA damage, several stimuli now appear to induce SDI1 independent of p53 function. We have examined the behavior of p53 and SDI1 in an isogeneic model by manipulating p53 status in normal diploid human fibroblasts using an amphotropic retroviral vector. Following DNA...

Topics

Bleomycin
Cell Division
Cellular Senescence
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
DNA Damage
Diploidy
Down-Regulation
G1 Phase
Gene Expression Regulation
Genes, p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Mutation

S Phase

Tumor Suppressor Protein p53

Ultraviolet Rays

Source

Identifiers

PMID: 7538902

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7538902-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Mutant p53 rescues human diploid cells from senescence without inhibiting the induction of SDI1/WAF1.PMID 7538902Read ↗

Escape from senescence in human diploid fibroblasts induced directly by mutant p53.Semantic proximity Read ↗

Bypass of Senescence After Disruption of p21 <sup> <i>CIP1/WAF1</i> </sup> Gene in Normal Diploid Human FibroblastsSemantic proximity Read ↗

p21Waf1/Cip1/Sdi1 induces permanent growth arrest with markers of replicative senescence in human tumor cells lacking functional p53Semantic proximity Read ↗

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