Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mouse zeta- and alpha-globin genes: embryonic survival, alpha-thalassemia, and genetic background effects.

Blood - 1 Aug 1997

Leder A, Daugherty C, Whitney B, Leder P

Abstract excerpt

A classical notion regarding the expression of murine embryonic zeta- and adult alpha-globin genes holds that there is a switch in globin production from the embryonic to the adult form during fetal development. Our previous in situ hybridization studies challenged this view, since both zeta- and alpha-globin mRNAs can be detected simultaneously in the earliest erythrocyte populations. This finding raises the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Gene Expression Regulation, Developmental
Share to Genotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Globins

Share to Mice, Inbred BALB C

Share to Mice, Inbred Strains

Share to Recombination, Genetic

Source

Identifiers

PMID: 9242562

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mouse zeta- and alpha-globin genes: embryonic survival, alpha-thalassemia, and genetic background effects.PMID 9242562Read ↗

zeta-/- Thalassemic mice are affected by two modifying loci and display unanticipated somatic recombination leading to inherited variation.Semantic proximity Read ↗

Reversal of Lethal - and β-Thalassemias in Mice by Expression of Human Embryonic GlobinsSemantic proximity Read ↗

Mouse model of human beta zero thalassemia: targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells.Semantic proximity Read ↗

WW6: an embryonic stem cell line with an inert genetic marker that can be traced in chimeras.Semantic proximity Read ↗

Developmental analysis of the Hba(th-J) mouse mutation: effects on mouse peri-implantation development and identification of two candidate genes.Semantic proximity Read ↗

Genome architecture of the human beta-globin locus affects developmental regulation of gene expression.Semantic proximity Read ↗

Distal transgene insertion affects CpG island maintenance during differentiation.Semantic proximity Read ↗

Imbalanced globin chain synthesis determines erythroid cell pathology in thalassemic miceSemantic proximity Read ↗

Human embryonic zeta-globin chain expression in deletional alpha-thalassemias.Semantic proximity Read ↗

An in vivo model for analysis of developmental erythropoiesis and globin gene regulation.Semantic proximity Read ↗

Alpha-thalassaemia.Semantic proximity Read ↗

Mutation of gene-proximal regulatory elements disrupts human epsilon-, gamma-, and beta-globin expression in yeast artificial chromosome transgenic mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.