Article
Imbalanced globin chain synthesis determines erythroid cell pathology in thalassemic mice
16 Jul 2009
Abstract excerpt
BACKGROUND: beta-thalassemia occurs from the imbalanced globin chain synthesis due to the absence or inadequate beta-globin chain production. The excessive unbound alpha-globin chains precipitate in erythroid precursors and mature red blood cells leading to ineffective erythropoiesis and hemolysis. DESIGN AND METHODS: In vitro globin chain synthesis in reticulocytes from different types of thalassemic mice was...