Mouse model of human beta zero thalassemia: targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells.

doi:10.1073/pnas.92.20.9259

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Article

Mouse model of human beta zero thalassemia: targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells.

Proceedings of the National Academy of Sciences of the United States of America - 26 Sept 1995

Ciavatta D J, Ryan T M, Farmer S C, Townes T M

Abstract excerpt

beta zero-Thalassemia is an inherited disorder characterized by the absence of beta-globin polypeptides derived from the affected allele. The molecular basis for this deficiency is a mutation of the adult beta-globin structural gene or cis regulatory elements that control beta-globin gene express...

Topics

Animals
Blotting, Southern
Chimera
Crosses, Genetic
Disease Models, Animal
Embryo, Mammalian
Erythrocytes
Female
Fertility
Gene Deletion
Globins
Hemoglobins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Heterozygote

Homozygote

Humans

Male

Mice

Mice, Inbred C57BL

Source

Open in PubMed Open full text

Identifiers

PMID: 7568113
DOI: 10.1073/pnas.92.20.9259
PMCID: PMC40964

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7568113-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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