Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Reversal of Lethal - and β-Thalassemias in Mice by Expression of Human Embryonic Globins

1 Nov 1998

Abstract excerpt

Genetic mutations that block alpha- or beta-globin gene expression in humans can result in severe and frequently lethal thalassemic phenotypes. Homozygous inactivation of the endogenous alpha- or beta-globin genes in mice results in corresponding thalassemic syndromes that are uniformly fatal in utero. In the current study, we show that the viability of these mice can be rescued by expression of human embryonic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Iron Metabolism and Disorders
Share to CRISPR and Genetic Engineering
Share to Hemoglobinopathies and Related Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 9787139
DOI: 10.1182/blood.v92.9.3057

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Reversal of Lethal - and β-Thalassemias in Mice by Expression of Human Embryonic GlobinsPMID 9787139Read ↗

Mouse zeta- and alpha-globin genes: embryonic survival, alpha-thalassemia, and genetic background effects.Semantic proximity Read ↗

Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunitiesSemantic proximity Read ↗

A human embryonic hemoglobin inhibits Hb S polymerization in vitro and restores a normal phenotype to mouse models of sickle cell disease.Semantic proximity Read ↗

Fetal hemoglobin silencing in humansSemantic proximity Read ↗

Recent advances in globin gene transfer for the treatment of beta-thalassemia and sickle cell anemiaSemantic proximity Read ↗

Differentiation of human embryonic stem cells into hematopoietic cells by coculture with human fetal liver cells recapitulates the globin switch that occurs early in developmentSemantic proximity Read ↗

LIN28B-mediated expression of fetal hemoglobin and production of fetal-like erythrocytes from adult human erythroblasts ex vivo.Semantic proximity Read ↗

Globin switches in yolk sac–like primitive and fetal-like definitive red blood cells produced from human embryonic stem cellsSemantic proximity Read ↗

zeta-/- Thalassemic mice are affected by two modifying loci and display unanticipated somatic recombination leading to inherited variation.Semantic proximity Read ↗

Fetal Globin Induction—Can It Cure β Thalassemia?Semantic proximity Read ↗

In vivo activation of the human δ-globin gene: the therapeutic potential in β-thalassemic mice.Semantic proximity Read ↗

An in vivo model for analysis of developmental erythropoiesis and globin gene regulation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.