Article
Human embryonic zeta-globin chain expression in deletional alpha-thalassemias.
Blood - 15 Jul 1992
Tang W, Luo H Y, Albitar M, Patterson M, Eng B, Waye J S, Liebhaber S A, Higgs D R, Chui D H
Abstract excerpt
zeta-Globin chain expression in carriers of a number of deletional alpha-thalassemias is investigated by radioimmunoassay. In a few cases, zeta-globin mRNAs are also studied. zeta-Globin chains are detected in (--SEA/), (--MED/), and (--SPAN/) deletions, but not in six other deletional mutations. These results suggest that the DNA element capable of suppressing zeta-globin expression in adult erythroid cells is...
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