Article
Alpha-thalassaemia.
Bailliere's clinical haematology - 1 Mar 1998
Bernini L F, Harteveld C L
Abstract excerpt
alpha-Thalassaemias are genetic defects extremely frequent in some populations and are characterized by the decrease or complete suppression of alpha-globin polypeptide chains. The gene cluster, which codes for and controls the production of these polypeptides, maps near the telomere of the short arm of chromosome 16, within a G + C rich and early-replicating DNA region. The genes expressed during the embryonic...
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