Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice.

doi:10.1016/s0960-9822(98)00021-9

Back to search

Article

Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice.

Current biology : CB - 1 Jan 2000

Barnes D E, Stamp G, Rosewell I, Denzel A, Lindahl T

Abstract excerpt

DNA ligase IV is the most recently identified member of a family of enzymes joining DNA strand breaks in mammalian cell nuclei [1] [2]. The enzyme occurs in a complex with the XRCC4 gene product [3], an interaction mediated via its unique carboxyl terminus [4] [5]. Cells lacking XRCC4 are hyperse...

Topics

Animals
Apoptosis
Central Nervous System
DNA Ligase ATP
DNA Ligases
Embryo, Mammalian
Gene Targeting
Genes, Lethal
Genotype
In Situ Nick-End Labeling
Mice
Mice, Inbred C57BL
Mice, Knockout

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.