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Article

Loss of DNA ligase IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF.

Nucleic acids research - 1 Oct 2008

Jayaram Sumithra, Ketner Gary, Adachi Noritaka, Hanakahi Les A

Abstract excerpt

The repair of DNA double-strand breaks by nonhomologous end-joining (NHEJ) is essential for maintenance of genomic integrity and cell viability. Central to the molecular mechanism of NHEJ is DNA ligase IV/XRCC4/XLF complex, which rejoins the DNA. During adenovirus (Ad5) infection, ligase IV is targeted for degradation in a process that requires expression of the viral E1B 55k and E4 34k proteins while XRCC4 and...

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Source

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Identifiers

PMID: 18782835
DOI: 10.1093/nar/gkn552
PMCID: PMC2566893

Genes

XRCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of DNA ligase IV prevents recognition of DNA by double-strand break repair proteins XRCC4 and XLF.PMID 18782835Read ↗

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