Type 1 diabetes and the control of dexamethazone-induced apoptosis in mice maps to the same region on chromosome 6.

doi:10.1006/geno.1995.1167

Back to search

Article

Type 1 diabetes and the control of dexamethazone-induced apoptosis in mice maps to the same region on chromosome 6.

Genomics - 10 Aug 1995

Penha-Gonçalves C, Leijon K, Persson L, Holmberg D

Abstract excerpt

Quantitative trait loci mapping was used to identify the chromosomal location of genes that contribute to increase the resistance to apoptosis induced in immature CD4+8+ thymocytes. An F2 intercross of the nonobese diabetic (NOD) mouse (displaying an apoptosis-resistance phenotype) and the C57BL/...

Topics

Animals
Apoptosis
Cells, Cultured
Chromosome Mapping
Dexamethasone
Diabetes Mellitus, Type 1
Drug Resistance
Female
Male
Mice
Mice, Inbred C57BL
Mice, Inbred NOD
Phenotype
Thymus Gland

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.