Article
Type 1 diabetes and the control of dexamethazone-induced apoptosis in mice maps to the same region on chromosome 6.
Genomics - 10 Aug 1995
Penha-Gonçalves C, Leijon K, Persson L, Holmberg D
Abstract excerpt
Quantitative trait loci mapping was used to identify the chromosomal location of genes that contribute to increase the resistance to apoptosis induced in immature CD4+8+ thymocytes. An F2 intercross of the nonobese diabetic (NOD) mouse (displaying an apoptosis-resistance phenotype) and the C57BL/6 mouse (displaying a nonresistance phenotype) was phenotypically analyzed and genotyped for 32 murine microsatellite...
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