A theoretical method for evaluating the relative importance of positive selection and neutral drift from observed base changes.

doi:10.1007/pl00006218

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Article

A theoretical method for evaluating the relative importance of positive selection and neutral drift from observed base changes.

Journal of molecular evolution - 1 Aug 1997

Otsuka J, Fukuchi S, Kikuchi N

Abstract excerpt

To evaluate the relative importance of positive selection and neutral drift from the nucleotide base changes observed in the homologous alignment of genes, a theoretical equation of base changes is formulated by including both the influence of selection and the base substitutions due to mutations...

Topics

Animals
Codon
Deoxyribonucleotides
Evolution, Molecular
Genetic Variation
Hemoglobins
Models, Genetic
Models, Theoretical
Mutagenesis
Myoglobin
Selection, Genetic
Vertebrates

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