The influence of selection on the evolutionary distance estimated from the base changes observed between homologous nucleotide sequences.

Abstract excerpt

In most studies of molecular evolution, the nucleotide base at a site is assumed to change with the apparent rate under functional constraint, and the comparison of base changes between homologous genes is thought to yield the evolutionary distance corresponding to the site-average change rate multiplied by the divergence time. However, this view is not sufficiently successful in estimating the divergence time of...

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