Article
Inverse correlation between loss of heterozygosity of the short arm of chromosome 12 and p15ink4B/p16ink4 gene inactivation in childhood acute lymphoblastic leukaemia.
British journal of haematology - 1 Jul 1997
Heyman M, Calero Moreno T, Liu Y, Grandér D, Rasool O, Borgonova-Brandter L, Merup M, Söderhäll S, Einhorn S
Abstract excerpt
Seventy-four patients with acute lymphoblastic leukaemia (ALL) were analysed with limited allelotyping to detect loss of heterozygosity on chromosome segments 6q, 9p, 12p and 13q in order to detect patterns of genetic alteration. In the case of chromosome 9, analyses were also performed to detect...
Topics
- Blotting, Southern
- Carrier Proteins
- Cell Cycle Proteins
- Child
- Child, Preschool
- Chromosomes, Human, Pair 12
- Chromosomes, Human, Pair 13
- Chromosomes, Human, Pair 6
- Chromosomes, Human, Pair 9
- Cyclin-Dependent Kinase Inhibitor p15