Canine tumour suppressor gene p53--mutation in a case of adenoma of circumanal glands.

doi:10.1023/a:1005820607258

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Article

Canine tumour suppressor gene p53--mutation in a case of adenoma of circumanal glands.

Veterinary research communications - 1 Jul 1997

Mayr B, Schaffner W, Botto I, Reifinger M, Loupal G

Abstract excerpt

Highly conserved regions of the tumour suppressor gene p53, including the typical human tumour hot spots (codons 175, 245, 248, 249, 273 and 282), were investigated in various canine neoplasms. A mutation CGG-->TGG (arginine-->tryptophan) was detected in codon 249 in an adenoma of the circumanal...

Topics

Adenoma
Anal Gland Neoplasms
Animals
Base Sequence
Dog Diseases
Dogs
Genes, p53
Humans
Mutation
Sequence Analysis

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