Tumour suppressor gene p53 mutation in a case of haemangiosarcoma of a dog.

doi:10.1556/AVet.50.2002.2.4

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Article

Tumour suppressor gene p53 mutation in a case of haemangiosarcoma of a dog.

Acta veterinaria Hungarica - 1 Jan 2002

Mayr B, Zwetkoff S, Schaffner G, Reifinger M

Abstract excerpt

Haemangiosarcomas of dogs were analysed by molecular genetic techniques. Regions of the tumour suppressor gene p53, including the well-known tumour hot spots (codons 175, 245, 248, 249, 273 and 282) were screened. A 24 bp deletion was detected in exon 5 of the gene.

Topics

Animals
DNA Primers
DNA, Neoplasm
Dog Diseases
Dogs
Genes, p53
Heart Neoplasms
Hemangiosarcoma
Liver Neoplasms
Male
Mutation
Polymerase Chain Reaction
Skin Neoplasms
Splenic Neoplasms

Source

Open in PubMed

Identifiers

PMID: 12113170
DOI: 10.1556/AVet.50.2002.2.4

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