Canine tumour suppressor gene p53 mutation in a case of anaplastic carcinoma of the intestine.

doi:10.1556/AVet.50.2002.1.5

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Article

Canine tumour suppressor gene p53 mutation in a case of anaplastic carcinoma of the intestine.

Acta veterinaria Hungarica - 1 Jan 2002

Mayr B, Reifinger M

Abstract excerpt

Tumours localised in the large bowel of dogs were subjected to molecular genetic studies. Highly conserved regions of the tumour suppressor gene p53, including typical tumour hot spots (codons 175, 245, 248, 249, 273 and 282), were analysed. A mutation CGG-->TGG (arginine-->tryptophan) was present in codon 249 in an anaplastic carcinoma in the caecum.

Topics

Animals
Carcinoma
Dog Diseases
Dogs
Genes, p53
Intestinal Neoplasms
Mutation
Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 12061233
DOI: 10.1556/AVet.50.2002.1.5

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