Article
Novel canine tumour suppressor gene p53 mutations in cases of skin and mammary neoplasms.
Veterinary research communications - 1 Aug 1999
Mayr B, Reifinger M, Alton K
Abstract excerpt
Exons 4 to 8 of the tumour suppressor gene p53 were analysed in 25 skin and 25 mammary tumours of 50 dogs. A 1 bp deletion (ACC-->AC) was detected in codon 89 in exon 4 in a squamous cell carcinoma. A missense mutation CGC-->CAC (arginine-->histidine) was present in codon 162 in exon 5 in a mammary adenocarcinoma. Moreover, a silent mutation occurred in codon 103 (serine) of exon 4 in a mammary adenoma. The...
Topics
- Adenocarcinoma
- Adenoma
- Amino Acid Sequence
- Animals
- Base Sequence
- Carcinoma, Squamous Cell
- Codon
- DNA Primers
- DNA, Neoplasm
- Dog Diseases
- Dogs
- Female
- Frameshift Mutation
- Genes, p53
- Mammary Neoplasms, Animal
- Molecular Sequence Data
- Mutation
- Mutation, Missense