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Article

The canine p53 gene is subject to somatic mutations in thypoid carcinoma.

Anticancer research - 1 Jan 2000

Devilee P, Van Leeuwen I S, Voesten A, Rutteman G R, Vos J H, Cornelisse C J

Abstract excerpt

In many different types of tumors in man and mouse, p53 is the tumor suppressor gene most frequently affected by a combination of somatic mutation and loss of the wildtype allele. In order to develop a molecular tool to study the genetic evolution of tumors in the dog, we have cloned an evolutionary conserved part of the canine homologue of p53. The isolated genomic segment, 534 bp in length, contains the 3' half...

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PMID: 7847847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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