Article
The canine p53 gene is subject to somatic mutations in thypoid carcinoma.
Anticancer research - 1 Jan 2000
Devilee P, Van Leeuwen I S, Voesten A, Rutteman G R, Vos J H, Cornelisse C J
Abstract excerpt
In many different types of tumors in man and mouse, p53 is the tumor suppressor gene most frequently affected by a combination of somatic mutation and loss of the wildtype allele. In order to develop a molecular tool to study the genetic evolution of tumors in the dog, we have cloned an evolution...
Topics
- Amino Acid Sequence
- Aneuploidy
- Animals
- Base Sequence
- DNA, Complementary
- DNA, Neoplasm
- Dogs
- Exons
- Genes, p53
- Genomic Library
- Humans
- Introns
- Molecular Sequence Data
- Mutation
- RNA, Messenger
- Sequence Homology, Nucleic Acid
- Thyroid Neoplasms