Article
Pax2/5 and Pax6 subdivide the early neural tube into three domains.
Mechanisms of development - 1 Apr 1999
Schwarz M, Alvarez-Bolado G, Dressler G, Urbánek P, Busslinger M, Gruss P
Abstract excerpt
The nested expression patterns of the paired-box containing transcription factors Pax2/5 and Pax6 demarcate the midbrain and forebrain primordium at the neural plate stage. We demonstrate that, in Pax2/5 deficient mice, the mesencephalon/metencephalon primordium is completely missing, resulting i...
Topics
- Animals
- Brain
- Cerebellum
- DNA-Binding Proteins
- Eye Proteins
- Female
- Gene Expression Regulation, Developmental
- Homeodomain Proteins
- Male
- Mesencephalon
- Mice
- Mice, Knockout
- Mice, Transgenic