Article
The small-eye mutation results in abnormalities in the lateral cortical migratory stream.
Brain research. Developmental brain research - 10 Sept 1998
Brunjes P C, Fisher M, Grainger R
Abstract excerpt
Mice with homozygous mutations of the Pax-6 gene exhibit a constellation of developmental problems including the absence of eyes and nasal cavities and problems in the movement of neuroblasts out of the germinal epithelium. In this paper, we demonstrate further disturbances in neuronal migration....
Topics
- Animals
- Cell Movement
- Cerebral Cortex
- Cerebral Ventricles
- DNA-Binding Proteins
- Eye Abnormalities
- Eye Proteins
- Homeodomain Proteins
- Homozygote
- Mice
- Mice, Neurologic Mutants
- Mutation