Article
Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations.
Nature - 15 Jan 2015
Deng Kai, Pertea Mihaela, Rongvaux Anthony, Wang Leyao, Durand Christine M, Ghiaur Gabriel, Lai Jun, McHugh Holly L, Hao Haiping, Zhang Hao, Margolick Joseph B, Gurer Cagan, Murphy Andrew J, Valenzuela David M, Yancopoulos George D, Deeks Steven G, Strowig Till, Kumar Priti, Siliciano Janet D, Salzberg Steven L, Flavell Richard A, Shan Liang, Siliciano Robert F
Abstract excerpt
Despite antiretroviral therapy (ART), human immunodeficiency virus (HIV)-1 persists in a stable latent reservoir, primarily in resting memory CD4(+) T cells. This reservoir presents a major barrier to the cure of HIV-1 infection. To purge the reservoir, pharmacological reactivation of latent HIV-1 has been proposed and tested both in vitro and in vivo. A key remaining question is whether virus-specific immune...
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