Article
Mutants of Saccharomyces cerevisiae defective in vacuolar function confirm a role for the vacuole in toxic metal ion detoxification.
FEMS microbiology letters - 15 Jul 1997
Ramsay L M, Gadd G M
Abstract excerpt
To directly define vacuolar role(s) in metal detoxification, we have examined the responses of vacuole-deficient mutants of Saccharomyces cerevisiae to several potentially toxic metals known to be mainly detoxified in the cytosol (Cu, Cd) or the vacuole (Co, Mn, Ni, Zn). Three mutants, deficient in targeting of vacuolar proteins, were used with JSR18 delta 1 being devoid of any vacuole-like structure while ScVatB...
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