Article
Saccharomyces cerevisiae mutants altered in vacuole function are defective in copper detoxification and iron-responsive gene transcription.
Yeast (Chichester, England) - 1 Dec 1997
Szczypka M S, Zhu Z, Silar P, Thiele D J
Abstract excerpt
The metal ions, Cu2+/+ and Fe3+/2+, are essential co-factors for a wide variety of enzymatic reactions. However, both metal ions are toxic when hyper-accumulated or maldistributed within cells due to their ability to generate damaging free radicals or through the displacement of other physiologic...
Topics
- Adaptor Proteins, Vesicular Transport
- Ceruloplasmin
- Copper
- Fungal Proteins
- Gene Expression Regulation, Fungal
- Genes, Fungal
- Homeostasis
- Inactivation, Metabolic
- Iron
- Membrane Proteins
- Mutation
- Oxidoreductases
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Transcription Factors
- Transcription, Genetic
- Vacuoles
- Vesicular Transport Proteins