Article
Vacuolar H+ -ATPase is involved in preventing heavy metal-induced oxidative stress in Saccharomyces cerevisiae.
Environmental microbiology - 1 Jun 2020
Techo Todsapol, Jindarungrueng Supat, Tatip Supinda, Limcharoensuk Tossapol, Pokethitiyook Prayad, Kruatrachue Maleeya, Auesukaree Choowong
Abstract excerpt
In Saccharomyces cerevisiae, vacuolar H+ -ATPase (V-ATPase) involved in the regulation of intracellular pH homeostasis has been shown to be important for tolerances to cadmium, cobalt and nickel. However, the molecular mechanism underlying the protective role of V-ATPase against these metals remains unclear. In this study, we show that cadmium, cobalt and nickel disturbed intracellular pH balance by triggering...
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