Iron sequestration by the yeast vacuole. A study with vacuolar mutants of Saccharomyces cerevisiae.

Abstract excerpt

To investigate iron uptake by the yeast vacuole, we examined iron accumulation and subcellular distribution in two Saccharomyces cerevisiae mutant strains with distinct alterations in vacuolar morpholgy and functions, the vacuolar protein targeting mutants vpt13 and vpt16. The mutant vpt13 is deficient in vacuolar acidification but possesses a morphologically normal vacuole, whereas vpt16 is devoid of any...

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