Article
Mechanistic analysis of cadmium toxicity in Saccharomyces cerevisiae.
FEMS microbiology letters - 12 Aug 2021
Zhao Yunying, Su Ruifang, Li Shiyun, Mao Yin
Abstract excerpt
As a potentially toxic heavy metal, Cadmium (Cd) can cause endoplasmic reticulum and oxidative stress, and thus lead to cell death. To explore the mechanisms of Cd toxicity, we investigated the UPRE-lacZ expression, the intracellular reactive oxygen species (ROS) and cell death in the 151 Cd-sensitive mutants of Saccharomyces cerevisiae in response to Cd stress. We identified 101 genes regulating UPRE-lacZ...
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