Article
Unraveling the genetic complexity of Drosophila stardust during photoreceptor morphogenesis and prevention of light-induced degeneration.
Genetics - 1 Aug 2007
Berger Sandra, Bulgakova Natalia A, Grawe Ferdi, Johnson Kevin, Knust Elisabeth
Abstract excerpt
Drosophila Stardust, a membrane-associated guanylate kinase (MAGUK), recruits the transmembrane protein Crumbs and the cytoplasmic proteins DPATJ and DLin-7 into an apically localized protein scaffold. This evolutionarily conserved complex is required for epithelial cell polarity in Drosophila embryos and mammalian cells in culture. In addition, mutations in Drosophila crumbs and DPATJ impair morphogenesis of...
Topics
- Alleles
- Animals
- Base Sequence
- DNA Primers
- Drosophila
- Drosophila Proteins
- Female
- Gene Expression
- Genes, Insect
- Guanylate Kinases
- Light
- Male
- Membrane Transport Proteins
- Morphogenesis