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Article

The Calliphora rpa mutant lacks the PDZ domain-assembled INAD signalling complex.

The European journal of neuroscience - 1 Nov 2000

Huber A, Belusic G, Da Silva N, Bähner M, Gerdon G, Draslar K, Paulsen R

Abstract excerpt

The visual transduction cascade of fly photoreceptors is a G protein-coupled phospholipase C-signalling pathway which is assembled into a supramolecular signalling complex by the PDZ (postsynaptic density protein-95, discs large, Z0-1) domain protein INAD (inactivation no afterpotential D). The norpA-encoded phospholipase Cbeta, the light-activated transient receptor potential (TRP) Ca2+ channel and an...

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PMID: 11069586
DOI: 10.1046/j.1460-9568.2000.00276.x

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The Calliphora rpa mutant lacks the PDZ domain-assembled INAD signalling complex.PMID 11069586Read ↗

Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signaling complex.Semantic proximity Read ↗

A multivalent PDZ-domain protein assembles signalling complexes in a G-protein-coupled cascade.Semantic proximity Read ↗

The PDZ scaffold protein INAD abolishes apparent store-dependent regulation of the light-activated cation channel TRP.Semantic proximity Read ↗

Functional INAD complexes are required to mediate degeneration in photoreceptors of the Drosophila rdgA mutant.Semantic proximity Read ↗

PDA (prolonged depolarizing afterpotential)-defective mutants: the story of nina's and ina's--pinta and santa maria, too.Semantic proximity Read ↗

A forward genetic screen in Drosophila melanogaster to identify mutations affecting INAD localization in photoreceptor cells.Semantic proximity Read ↗

Assembly of the Drosophila phototransduction cascade into a signalling complex shapes elementary responses.Semantic proximity Read ↗

Interaction of eye protein kinase C and INAD in Drosophila. Localization of binding domains and electrophysiological characterization of a loss of association in transgenic flies.Semantic proximity Read ↗

Phospholipase C and termination of G-protein-mediated signalling in vivo.Semantic proximity Read ↗

The rpa (receptor potential absent) visual mutant of the blowfly (Calliphora erythrocephala) is deficient in phospholipase C in the eye.Semantic proximity Read ↗

Phosphoinositide-mediated phototransduction in Drosophila photoreceptors: the role of Ca2+ and trp.Semantic proximity Read ↗

Independent anchoring and assembly mechanisms of INAD signaling complexes in Drosophila photoreceptors.Semantic proximity Read ↗

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