Article
Functional differences in the interaction of arrestin and its splice variant, p44, with rhodopsin.
Biochemistry - 29 Jul 1997
Pulvermüller A, Maretzki D, Rudnicka-Nawrot M, Smith W C, Palczewski K, Hofmann K P
Abstract excerpt
Arrestin quenches signal transduction in rod photoreceptors by blocking the catalytic activity of photoactivated phosphorylated rhodopsin toward the G protein, transducin (Gt). Rod cells also express a splice variant of arrestin, termed p44, in which the last 35 amino acids are replaced by a single Ala. In contrast to arrestin, this protein has been reported to bind to both the phosphorylated and...
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