Article
Differential interaction of spin-labeled arrestin with inactive and active phosphorhodopsin.
Proceedings of the National Academy of Sciences of the United States of America - 28 Mar 2006
Hanson Susan M, Francis Derek J, Vishnivetskiy Sergey A, Kolobova Elena A, Hubbell Wayne L, Klug Candice S, Gurevich Vsevolod V
Abstract excerpt
Arrestins regulate signaling and trafficking of G protein-coupled receptors by virtue of their preferential binding to the phosphorylated active form of the receptor. To identify sites in arrestin involved in receptor interaction, a nitroxide-containing side chain was introduced at each of 28 different positions in visual arrestin, and the dynamics of the side chain was used to monitor arrestin interaction with...
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