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Article

Crystal structure of p44, a constitutively active splice variant of visual arrestin.

Journal of molecular biology - 9 Mar 2012

Granzin Joachim, Cousin Anneliese, Weirauch Moritz, Schlesinger Ramona, Büldt Georg, Batra-Safferling Renu

Abstract excerpt

Visual arrestin specifically binds to photoactivated and phosphorylated rhodopsin and inactivates phototransduction. In contrast, the p44 splice variant can terminate phototransduction by binding to nonphosphorylated light-activated rhodopsin. Here we report the crystal structure of bovine p44 at a resolution of 1.85 Å. Compared to native arrestin, the p44 structure reveals significant differences in regions...

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Identifiers

PMID: 22306737
DOI: 10.1016/j.jmb.2012.01.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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