Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of loss of heterozygosity in the APC tumor suppressor gene in nonpapillary renal cell carcinoma by microdissection and polymerase chain reaction.

Urological research - 1 Jan 1997

Böhm M, Wieland I, Stinhöfer C, Otto T, Rübben H

Abstract excerpt

The role of the APC (adenomatous polyposis coli) tumor suppressor gene in the genesis of nonpapillary renal cell carcinoma is addressed. The frequency of allelic deletion in the APC gene was analyzed using microdissection of the tumor specimens and a PCR (polymerase chain reaction)-based assay for the detection of intragenic loss of heterozygosity (LOH). Twelve of 29 carcinomas investigated were informative...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over
Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to APC gene

Share to Gene Deletion

Share to Genetic Carrier Screening

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 9228666
DOI: 10.1007/BF00941976

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Detection of loss of heterozygosity in the APC tumor suppressor gene in nonpapillary renal cell carcinoma by microdissection and polymerase chain reaction.PMID 9228666Read ↗

Intragenic PTEN/MMAC1 loss of heterozygosity in conventional (clear-cell) renal cell carcinoma is associated with poor patient prognosis.Semantic proximity Read ↗

Somatic mutation of PTEN in bladder carcinoma.Semantic proximity Read ↗

Frequency of allele loss of DCC, p53, RBI, WT1, NF1, NM23 and APC/MCC in colorectal cancer assayed by fluorescent multiplex polymerase chain reaction.Semantic proximity Read ↗

Loss of Heterozygosity at the p53, RB, DCC and APC Tumor Suppressor Gene Loci in Human Bladder CancerSemantic proximity Read ↗

Loss of heterozygosity at APC and MCC genes of oral cancer and leukoplakia tissues from Indian tobacco chewers.Semantic proximity Read ↗

Analysis of APC allelic imbalance/loss of heterozygosity and APC protein expression in cutaneous squamous cell carcinomas.Semantic proximity Read ↗

Loss of heterozygosity at 5q21 in non-small cell lung cancer: a frequent event but without evidence of apc mutation.Semantic proximity Read ↗

Hypermethylation of the APC promoter but lack of APC mutations in myxoid/round-cell liposarcoma.Semantic proximity Read ↗

Absence of APC gene mutation in the mutation cluster region in hepatocellular carcinoma.Semantic proximity Read ↗

Loss of heterozygosity affecting the APC and MCC genetic loci in patients with primary breast carcinomas.Semantic proximity Read ↗

Allelic loss at 10q23.3 but lack of mutation of PTEN/MMAC1 in chromophobe renal cell carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.