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Article

Hypermethylation of the APC promoter but lack of APC mutations in myxoid/round-cell liposarcoma.

International journal of cancer - 15 Nov 2006

Sievers Sonja, Fritzsch Carla, Lehnhardt Marcus, Zahn Susanne, Kutzner Nadine, Kuhnen Cornelius, Müller Oliver

Abstract excerpt

The adenomatous polyposis coli (APC) protein is a key component of the WNT signalling pathway wherein it acts as a scaffolding protein in controlling the level of the proto-oncoprotein beta-catenin. Although APC has been shown to be genetically or epigenetically inactivated in a variety of carcinomas, little is known about its role in sarcoma. Liposarcomas (LPSs) are the second most common soft tissue sarcoma in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Enzyme-Linked Immunosorbent Assay

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Source

Identifiers

PMID: 16858687
DOI: 10.1002/ijc.22117

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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