Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intragenic PTEN/MMAC1 loss of heterozygosity in conventional (clear-cell) renal cell carcinoma is associated with poor patient prognosis.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 May 2002

Velickovic Marija, Delahunt Brett, McIver Bryan, Grebe Stefan K G

Abstract excerpt

Inactivation of the PTEN/MMAC1 tumor suppressor gene has been linked to tumor progression in several human malignancies. However, the role of PTEN/MMAC1 in the development and progression of the major renal cell carcinoma morphotypes remains controversial. We examined microdissected specimens from 80 conventional (clear cell) renal cell carcinomas (cRCC), 27 papillary renal cell carcinomas (pRCC), and 16...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma, Clear Cell
Share to Carcinoma, Renal Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 10

Share to Kidney Neoplasms

Share to Loss of Heterozygosity

Share to Phosphoric Monoester Hydrolases

Share to PTEN Phosphohydrolase

Share to Survival Analysis

Source

Identifiers

PMID: 12011252
DOI: 10.1038/modpathol.3880551

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intragenic PTEN/MMAC1 loss of heterozygosity in conventional (clear-cell) renal cell carcinoma is associated with poor patient prognosis.PMID 12011252Read ↗

PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate.Semantic proximity Read ↗

Allelic loss at 10q23.3 but lack of mutation of PTEN/MMAC1 in chromophobe renal cell carcinoma.Semantic proximity Read ↗

Genomic alterations and instabilities in renal cell carcinomas and their relationship to tumor pathology.Semantic proximity Read ↗

PTEN/MMAC1/TEP1 mutations in human primary renal-cell carcinomas and renal carcinoma cell lines.Semantic proximity Read ↗

Distal nephron renal tumors: microsatellite allelotype.Semantic proximity Read ↗

Application of Chromosome Microarray Analysis for the Differential Diagnosis of Low-grade Renal Cell Carcinoma With Clear Cell and Papillary Features.Semantic proximity Read ↗

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression.Semantic proximity Read ↗

PTEN/MMAC1 mutations in hepatocellular carcinomas: somatic inactivation of both alleles in tumors.Semantic proximity Read ↗

Expression of PTEN in renal cell carcinoma and its relation to tumor behavior and growthSemantic proximity Read ↗

Infrequent genetic alterations of the tumor suppressor gene PTEN/MMAC1 in squamous cell carcinoma of the oral cavity.Semantic proximity Read ↗

Cytogenetic and molecular findings in 75 clear cell renal cell carcinomasSemantic proximity Read ↗

Losses at 3p common deletion sites in subtypes of kidney tumours: histopathological correlations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.