Article
Presenilin-1 polymorphism and hereditary cerebral hemorrhage with amyloidosis, Dutch type.
Annals of neurology - 1 Jul 1997
Bornebroek M, Haan J, Backhovens H, Deutz P, Van Buchem M A, van den Broeck M, Bakker E, Roos R A, Van Broeckhoven C
Abstract excerpt
Hereditary cerebral hemorrhage with amyloidosis, Dutch type, caused by a mutation at codon 693 of the amyloid beta precursor protein gene, is characterized by amyloid beta deposition resulting in recurrent strokes and dementia. Recent data suggest that presenilin-1 may be biologically linked to cerebral amyloid beta deposition. The intronic presenilin-1 polymorphism published by Wragg and colleagues (1996) was...
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