Article
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type.
Science (New York, N.Y.) - 1 Jun 1990
Levy E, Carman M D, Fernandez-Madrid I J, Power M D, Lieberburg I, van Duinen S G, Bots G T, Luyendijk W, Frangione B
Abstract excerpt
An amyloid protein that precipitates in the cerebral vessel walls of Dutch patients with hereditary cerebral hemorrhage with amyloidosis is similar to the amyloid protein in vessel walls and senile plaques in brains of patients with Alzheimer's disease, Down syndrome, and sporadic cerebral amyloi...
Topics
- Aged
- Aged, 80 and over
- Alleles
- Alzheimer Disease
- Amino Acid Sequence
- Amyloid
- Amyloid beta-Protein Precursor
- Amyloidosis
- Base Sequence
- Brain Chemistry
- Cerebral Hemorrhage
- Cerebrovascular Disorders
- DNA
- Deoxyribonucleases, Type II Site-Specific
- Exons
- Female
- Genes, Dominant
- Humans