Article
Dutch hereditary cerebral amyloid angiopathy: structural lesions and apolipoprotein E genotype.
Annals of neurology - 1 May 1997
Bornebroek M, Haan J, Van Duinen S G, Maat-Schieman M L, Van Buchem M A, Bakker E, Van Broeckhoven C, Roos R A
Abstract excerpt
Hereditary cerebral hemorrhage with amyloidosis-Dutch type is caused by a mutation at codon 693 of the beta amyloid precursor protein gene. The disease is clinically characterized by strokes and dementia. In addition to cerebral plaques, cerebral amyloid angiopathy is the pathological hallmark. We investigated the correlation between radiological (white matter hyperintensities and focal lesions on magnetic...
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